The film centers on thirteen-year-old Meg Murry and the struggles she has faced since the disappearance of her father when she was a young girl. Meg's father, Alex, was a scientist who studied astrophysics. Meg and her mother both theorize that Alex was somehow transported to another dimension when working on an astrophysics problem. One fateful night, an eccentric named Mrs. Whatsit comes to the Murry house and informs them that Alex's father was working on a type of space-travel called the Tesseract when he disappeared. Meg finds out that her father is trapped on the planet Camaztotz. The movie follows Meg, her brother Charles and her friend Calvin as they attempt to rescue her father and bring him home.
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